What is Pseudogout?

Pseudogout, also known as calcium pyrophosphate deposition (CPPD) disease, is a type of arthritis that occurs when calcium pyrophosphate crystals accumulate in the joints, leading to inflammation and pain. These crystals deposit in and around the joint tissues, causing symptoms similar to gout, another type of arthritis caused by the buildup of uric acid crystals.

Causes of Pseudogout

The exact cause of pseudogout is not fully understood, but it is associated with the formation of calcium pyrophosphate crystals in the joints. These crystals are believed to result from the aging process, as they are more commonly found in older individuals. However, other factors, such as genetics and certain medical conditions, may also contribute to the development of pseudogout.

Symptoms of Pseudogout

The most common symptoms of pseudogout are sudden and intense joint pain, swelling, and redness, typically affecting one or a few joints. The knees are commonly involved, but other joints such as the wrists, ankles, shoulders, and elbows can also be affected. The pain and inflammation can be severe and may cause limited mobility in the affected joint.

Diagnosing pseudogout involves a combination of a patient’s medical history, physical examination, and imaging studies. X-rays and joint aspiration (arthrocentesis) are essential in confirming the presence of calcium pyrophosphate crystals in the joint fluid, which is the definitive diagnostic test for pseudogout.


Diagnosing pseudogout involves:

  • Medical History: Information about the patient’s symptoms and medical history.
  • Physical Examination: Assessment of joint inflammation and pain.
  • Imaging: X-rays and other imaging tests may show characteristic findings such as calcifications within joint cartilage.
  • Joint Fluid Analysis: Aspiration of joint fluid and examination under a microscope can reveal calcium pyrophosphate crystals.

Treatment for Pseudogout

Treatment for pseudogout aims to relieve symptoms and prevent future flare-ups. It typically includes:

  1. Nonsteroidal anti-inflammatory drugs (NSAIDs): These medications help reduce pain and inflammation associated with pseudogout.
  2. Colchicine: Colchicine is another medication that can be used to alleviate the symptoms of pseudogout.
  3. Corticosteroids: In cases of severe inflammation or when other treatments are ineffective, corticosteroids may be prescribed to reduce inflammation.
  4. Joint aspiration: In some cases, the affected joint may be drained of fluid (aspiration) to relieve pain and pressure.
  5. Physical therapy: Physical therapy can be beneficial in improving joint mobility and strength, especially after a pseudogout flare-up.
  6. Lifestyle changes: Maintaining a healthy weight, avoiding excessive alcohol consumption, and staying hydrated may help reduce the risk of future flare-ups.


While pseudogout cannot always be prevented, certain measures can help reduce the risk of acute attacks:

  • Hydration: Staying well-hydrated may reduce the risk of crystal formation.
  • Regular Exercise: Regular physical activity helps maintain joint function and flexibility.
  • Managing Underlying Conditions: Treating underlying medical conditions can help prevent pseudogout.

If you suspect you have pseudogout or are experiencing sudden joint pain and inflammation, it’s important to consult a healthcare provider for proper diagnosis and management. A healthcare provider can recommend appropriate treatment options based on your specific situation.



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